Considerazioni

Uncaria Tormentosa

This page report syntethically principal information about UNCARIA TORMENTOSA and HIV. The complete research text is available only in Italian language and is published in the volume: Bianchi, Adamoli, " Piante Medicinali e AIDS", Ed. Tecniche Nuove, 1997. For a better result we suggest to print this document in landscape mode.

IN VITRO DATA

Uncaria Tormentosa stimulates Macrophages, Lymphocytes T and B production (Stuppner et al., 1992; Immodal 1995; Wagner et al., 1985a)

IN VIVO DATA

Duration (weeks) Type of Study Principal Markers and
Study stage (F)
Starting CD4
(mm³)
and/or Stage
Starting Viral Load(CV) (copies/ml) Results Treated Controls Total treated cases

Reference Dosage

Immodal 1995 2-3 cpr/die, in oxindolic alkaloids (= 520-78/700-1050 m g)
DNR
CC CD4, CD8, CD4/CD8 DNR Improvement 44 44

Clinical Data - Legenda
DNR = Data Not Available X = Media
M = Improves A = Years Me = Median
S = Synthesis N = Natural SN = Permanently
CC = Clinical Casuistics Negative
Q = Questionnaire S = Stabiliser
SCC = Controlled Cl. Study SA = Open Study
SO = Observational Study SC = Clinical Study

Considerations:

Uncaria tomentosa is an Amazonian plant devoid of toxicity
The plant possesses an interesting antiphlogistic (due to quinovic acid glycosides) and immunostimulant ( due to pentacyclic type oxindolic alkaloids) in vitro proven activity.
Any statement on a clinical benefit in HIV infection has to be retained hasty in absence of a rigorous study on a significative amount of patients following accurate evaluation criteria.

Riferimenti bibliografici

Aquino R, De Simone F, Pizza C, Conti C, Stein ML (1989)
Plant Metabolites. Structure and in Vitro Antiviral Activity of Quinovic Acid Glycosides from Uncaria tomentosa and Guettarda platypada.
J Nat Prod, vol 52: 679-685

Aquino R, De Feo V, De Simone F, Pizza C, Cirino G (1991)
Plant Metabolites. New Compounds and Antiinflammatory Activity of Uncaria tomentosa.
J Nat Prod, vol 54: 453-459

Iaccarino FP, Tirillini B, Stoppini AM (1995a)
Studi tossicologici sugli estratti di corteccia di Uncaria Tomentosa, DC
Acta Phytoter, vol 1(2): 37-44

Iaccarino FP (1995b)
In Uncaria Tomentosa (Will) DC
Stampata da Pegaso Omeopatici (materiale per medici)

Immodal Pharmaka GmbH (1995)
Krallendorn. Uncaria Tomentosa (Willd.) DC: Root Extract. Information for Physicians and Dispensing Chemists (3° Rev Ed)

Laus K e Keplinger D (1994)
Separation of Stereoisomeric Oxindole Alkaloids from Uncaria Tomentosa by High Performance Liquid Cromatography.
J Chromatogr, vol 662: 243-249

Liu J e Mori A (1993)
Antioxidant and Free Radicals Scavenging Activities of Gastrodia Elata Bl. and Uncaria Rhynchophylla (Miq) Jacks.
Neuropharmacology, vol 31(12): 1287-1298

Liu HM, Jiang Z e Feng XZ (1993)
New Oxindole Alkaloid Glycosides from Uncaria sinensis.
Yao-Hsueh-Hsueh-Pao, vol 28(11): 849-853

Mok JG, Chang P, Lee KH, Kam TS e Goh SH (1992)
Cardiovascular Responses in the Normotensive Rat Produced by Intervenous Injection of Gambirine Isolated from Uncaria Callophylla Bl. ex Korth.
J Ethnopharm, vol 36: 219-223

Obregon Vilches LE (1994)
"Uña de Gato". Genere Uncaria: Estudio Botanicos, Quimicos y Farmacologicos de Uncaria Tomentosa. Uncaria Guianensis.
Instituto de Fitoterapia Americano. Lima. 2° Edicion.

Pino A, Salazar M, Vergas K, Ayala V, Rodriguez J, Almonte F, Morales A (1996)
Immunostimolant and Toxic Effect of Aqueous Extract from Uncaria Tomentosa Will D.C. in Mice and Rats.
Symposium on Phytomedicine, Munchen 1996 (Abstract)

Rizzi R, Re F, Bianchi A, De Feo V, De Simone F, Bianchi L, Stivala LA (1993)
Mutagenic and Antimutagenic Activities of Uncaria Tomentosa and its Extracts-
J Ethnopharm, vol 38: 63-77

Stuppner H, Sturm S, Konwalinka G (1992)
HPLC Analysis of the Main Oxindole Alkaloids from Uncaria Tomentosa.
Chromatographia, vol 34: 597-600

Wagner H, Kreutzkam B, Jurcic K (1985a)
Die Alkaloide von Uncaria tomentosa und ihre Phagozytose steigerde Wirkung.
Planta Med, vol 51, 419-423

Wagner H, Prokrisch A, Vollmar A, Kreutzkam B, Jurcic K (1985b)
In Vitro Phagocytosis Stimulation by Isolated Plant Materials in a Chemoluminescence-phagocytosis Model
Planta Med, vol. 51: 139-143